Channel 105385-sk_gp

General data

• ICG id: 53
• ModelDB id: 105385
• Reference: Mercer JN, Chan CS, Tkatch T, Held J, Surmeier DJ (2007): Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons.

Metadata classes

• Animal Model: mouse
• Brain Area: rostral to midlevel, external globus pallidus (GPe), basal ganglia, globus pallidus (GP)
• Neuron Type: globus pallidus (GP) neuron
• Runtime Q: Q2
• Subtype: SK

Metadata generic

• Age: P17-22
• Authors: M Migliore, J Held
• Comments: Sk calcium-dependent k current. Adapted from ahp current in model of ca3 pyramidal neuron in migliore et al. (1995), model no. 3263, with modified values for gbar (gkahpbar), addition of temperature dependence, and modified text. Note that mod files here resemble those of maurice et al. (2004), model no. 98005, but this is not mentioned in paper. Animal model is from experiments in paper. Some channel kinetics were fit to data in paper, or constrained by previous studies of rat globus pallidus neurons (baranauskas et al. 1999, 2003) and others (see paper). This channel was adapted from previous model of rodent ca3 pyramidal neuron (migliore et al 1995).
• Runtime: 69.119
• Temperature: Model has temperature dependence, with q10 set to 3 and original kinetics at 22 deg C. Recordings in paper were done at 22 deg C, and simulations at 23 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp