Channel 45539-kc_fast

General data

• ICG id: 2901
• ModelDB id: 45539
• Reference: Traub RD, Contreras D, Whittington MA (2005): Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo.

Metadata classes

• Animal Model: rat
• Brain Area: layer 5, layer 2/3, cortex, auditory cortex, thalamocortical circuit, parietal cortex, layer 6, layer 4, barrel cortex
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell, fast rhythmic bursting (FRB), thalamocortical relay cell (TC, TCR), thalamic reticular (RE) cell, regular spiking (RS) cell, intrinsically bursting (IB) cell, fast-spiking (FS) cell, low-threshold spiking (LTS) cell, interneuron, stellate cell, spiny cell, nontufted cell, tufted cell
• Runtime Q: Q3
• Subtype: C

Metadata generic

• Age: adult
• Authors: T Morse, M Lazarewicz.
• Comments: Modeling based on traub et al. (1994) and traub et al. (2003c), conductances from traub et al. 2003 and cunningham et al. 2004. This file: potassium c type current for rd traub 2003, model no. 20756. Modified with simple speed up *2 factor at bottom by t morse (lines 73-75), implemented by m lazarewicz, 2003. Modeling study, with many neurons in the cortex and thalamus. This channel is one of two k(c) models, but it is unclear which one is used in each cell type. The animal model info here is from electrophysiology experiments also in this paper, both in vivo and in vitro.
• Runtime: 73.728
• Temperature: Channel model has no temperature dependence. Experiments done at 34-37 deg C, simulations likely done at physiological temperatures.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp