Channel 45539-kahp_deeppyr

General data

• ICG id: 2898
• ModelDB id: 45539
• Reference: Traub RD, Contreras D, Whittington MA (2005): Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo.

Metadata classes

• Animal Model: rat
• Brain Area: layer 5, layer 2/3, cortex, auditory cortex, thalamocortical circuit, parietal cortex, layer 6, layer 4, barrel cortex
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell, fast rhythmic bursting (FRB), thalamocortical relay cell (TC, TCR), thalamic reticular (RE) cell, regular spiking (RS) cell, intrinsically bursting (IB) cell, fast-spiking (FS) cell, low-threshold spiking (LTS) cell, interneuron, stellate cell, spiny cell, nontufted cell, tufted cell
• Runtime Q: Q3
• Subtype: AHP

Metadata generic

• Age: adult
• Authors: M Lazarewicz.
• Comments: Modeling based on traub et al. (1994) and traub et al. (2003c), conductances from traub et al. 2003, model no. 20756, and cunningham et al. 2004. This file: potassium aho (slower) type current for rd traub 2005. Modified by t morse to make slower than the slow suppyrfrb, suppyrrs ahp (line 63). Note the time constant at zero cai is 1 second here and 100ms in the slow ahp. Implemented by m lazarewicz, 2003. Modeling study, with many neurons in the cortex and thalamus. This channel is primarily used in deep pyramidal neurons. The animal model info here is from electrophysiology experiments also in this paper, both in vivo and in vitro.
• Runtime: 72.645
• Temperature: Channel model has no temperature dependence. Experiments done at 34-37 deg C, simulations likely done at physiological temperatures.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp