Channel 112834-bkkca

General data

• ICG id: 139
• ModelDB id: 112834
• Reference: Wolf JA, Moyer JT, Lazarewicz MT, Contreras D, Benoit-Marand M, O'Donnell P, Finkel LH (2005): NMDA/AMPA ratio impacts state transitions and entrainment to oscillations in a computational model of the nucleus accumbens medium spiny projection neuron.

Metadata classes

• Animal Model: rat
• Brain Area: basal ganglia, nucleus accumbens (NAcc)
• Neuron Region: soma, dendrites
• Neuron Type: medium spiny projection (MSP) neuron
• Runtime Q: Q4 (slow)
• Subtype: BK

Metadata generic

• Age: 48-59 days
• Authors: M Lazarewicz.
• Comments: Large conductance (bk) kca channel for nucleus accumbens model. Equations from shao et al. (1999), written by m lazarewicz, 2001. No apparent modeldb ancestor. Animal model is from experiments in paper. Channel data comes mostly from churchill & macvicar 1998, on adult rat accumbal cells, kinetics originally from shao et al. 1999 from rat hippocampal pyramidal cells.
• Runtime: 79.212
• Temperature: No apparent temperature dependence. Experiments done at 33-35 deg C, simulations at 35 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp