Channel 147867-h

General data

• ICG id: 3155
• ModelDB id: 147867
• Reference: Narayanan R, Chattarji S (2010): Computational analysis of the impact of chronic stress on intrinsic and synaptic excitability in the hippocampus.

Metadata classes

• Animal Model: rat, guinea pig
• Brain Area: CA3, hippocampus
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q3
• Subtype: h

Metadata generic

• Authors: R Narayanan, M Migliore
• Comments: I-h channel from magee 1998. Modified to make slower according to sfn 2006 poster 342.23. The peak activation time constant of ih is around 100ms, around twice slower than that at ca1. And half is around -89 mv, which is similar to what one sees in ca1 dendrites. Ancestry is unclear, no modeldb ancestors listed. Modeling study, uses channel kinetics (migliore et al. 1995, 1999) and experimental data (vyas et al. 2002) from previous studies, mostly using rats and sometimes other animals (guinea pig).
• Runtime: 14.085
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp