Channel 45539-ar

General data

• ICG id: 2887
• ModelDB id: 45539
• Reference: Traub RD, Contreras D, Whittington MA (2005): Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo.

Metadata classes

• Animal Model: rat
• Brain Area: layer 5, layer 2/3, cortex, auditory cortex, thalamocortical circuit, parietal cortex, layer 6, layer 4, barrel cortex
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell, fast rhythmic bursting (FRB), thalamocortical relay cell (TC, TCR), thalamic reticular (RE) cell, regular spiking (RS) cell, intrinsically bursting (IB) cell, fast-spiking (FS) cell, low-threshold spiking (LTS) cell, interneuron, stellate cell, spiny cell, nontufted cell, tufted cell
• Runtime Q: Q1 (fast)
• Subtype: anomalous rectifier (AR)

Metadata generic

• Age: adult
• Authors: M Lazarewicz.
• Comments: Modeling based on traub et al. (1994) and traub et al. (2003c), conductances from traub et al. 2003 and cunningham et al. 2004. Ar channel: anomalous rectifier current for rd traub 2003, model no. 20756, with minimal changes. No apparent changes to kinetics. Implemented by m lazarewicz, 2003. Modeling study, with many neurons in the cortex and thalamus. All neurons contain this channel. The animal model info here is from electrophysiology experiments also in this paper, both in vivo and in vitro.
• Runtime: 12.689
• Temperature: Channel model has no temperature dependence. Experiments done at 34-37 deg C, simulations likely done at physiological temperatures.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp