Channel 98005-hcn12_ch

General data

• ICG id: 2645
• ModelDB id: 98005
• Reference: Maurice N, Mercer J, Chan CS, Hernandez-Lopez S, Held J, Tkatch T, Surmeier DJ (2004): D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons.

Metadata classes

• Animal Model: Sprague-Dawley, mouse, rat, C57BL/6
• Brain Area: basal ganglia, striatum (basal ganglia)
• Neuron Region: soma, dendrites
• Neuron Type: interneuron, cholinergic
• Runtime Q: Q4 (slow)
• Subtype: HCN

Metadata generic

• Age: 3-5 weeks
• Authors: J Held, M Nolan
• Comments: C-amp modulated cation channel. Kinetic model of hcn2 channel gating from wang et al (2002), model no. 19176, with various modifications. J held's adaptation to suit hcn1+2. Animal model is from experiments in paper. Hcn channel kinetics come from previous model of thalamocortical relay cells (wang et al. 2002).
• Runtime: 16.799
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp