Channel 97860-hcn_siegelbaum

General data

• ICG id: 2562
• ModelDB id: 97860
• Reference: Chan CS, Guzman JN, Ilijic E, Mercer JN, Rick C, Tkatch T, Meredith GE, Surmeier DJ (2007): 'Rejuvenation' protects neurons in mouse models of Parkinson's disease.

Metadata classes

• Animal Model: mouse
• Brain Area: basal ganglia, substantia nigra pars compacta (SNc)
• Neuron Region: single compartment
• Neuron Type: dopaminergic
• Runtime Q: Q4 (slow)
• Subtype: h

Metadata generic

• Age: adult (<P28), juvenile (<P21)
• Authors: J Held
• Comments: Hcn current. Model and parameters from wang et al. (2002), model no. 19176, with several changes to parameters and implementation. Animal model comes from experiments in paper. Channel kinetics are mostly from unspecified sources.
• Runtime: 16.722
• Temperature: Model has temperature dependence, with original kinetics at 22 deg C, and q10a, q10v set to 1.5 and 4, respectively.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp