Channel 9769-h

General data

• ICG id: 2546
• ModelDB id: 9769
• Reference: Poolos NP, Migliore M, Johnston D (2002): Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, apical dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: h

Metadata generic

• Age: 6-10 weeks old
• Authors: M Migliore
• Comments: I-h channel with dendritic distribution and activation kinetics from magee 1998 for distal dendrites, default values are for dendrites and low na. Non-inactivating non-specific cation current. No modeldb ancestors. This paper features experimental data as well as modeling. The animal model info below reflects the experimental data here. Both the ancestor and this current model feature rat ca1 pyramidal neuron.
• Runtime: 13.796
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp