Channel 114394-h

General data

• ICG id: 232
• ModelDB id: 114394
• Reference: Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008): Action potential generation requires a high sodium channel density in the axon initial segment.

Metadata classes

• Animal Model: Wistar, rat
• Brain Area: somatosensory cortex, layer 5, cortex
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: h

Metadata generic

• Age: 2-4 weeks old
• Authors: S Hallermann
• Comments: Deterministic model of kinetics and voltage-dependence of ih-currents in layer 5 pyramidal neuron, implemented by s hallermann. Predominantly hcn1 / hcn2. Taken from kole et al. (2006), model no. 64195, with modified parameters (lines 23-28), but the same kinetics. This paper contains experimental results from rats, as well as modeling based on a previous model. The animal model info here is from the experimental results, the morphology of the model is not specified, could also come from the ancestor model.
• Runtime: 13.718
• Temperature: Model has temperature dependence. Kinetics were originally recorded at 34 deg C, simulations run here at 37 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp