Channel 19176-hcn2

General data

• ICG id: 1546
• ModelDB id: 19176
• Reference: Wang J, Chen S, Nolan MF, Siegelbaum SA (2002): Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling.

Metadata classes

• Animal Model: generic
• Brain Area: thalamus
• Neuron Type: thalamocortical relay cell (TC, TCR)
• Runtime Q: Q4 (slow)
• Subtype: h

Metadata generic

• Authors: M Nolan, S Chen.
• Comments: Kinetic model of hcn2 channel gating from wang et al. (2002). Channel is coupled to affinity of camp binding site. This mod file does not appear to have an ancestor. No ancestor model. Modeling uses previous study on the thalamocortical circuit. No animal model mentioned in paper so it is considered generic.
• Runtime: 16.811
• Temperature: Experiments done at 22 deg C, simulations at 36 deg C, q10=4 for model.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp