Channel 135839-caL3d

General data

• ICG id: 832
• ModelDB id: 135839
• Reference: Yu Y, Shu Y, McCormick DA (2008): Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics.

Metadata classes

• Animal Model: ferret
• Brain Area: somatosensory cortex, layer 5, prefrontal cortex, cortex
• Neuron Type: pyramidal cell
• Runtime Q: Q4 (slow)
• Subtype: high threshold

Metadata generic

• Age: 7-10 weeks old
• Authors: A Destexhe
• Comments: High threshold ca2+ channel, 2-state kinetics with sigmoidal voltage-dependence, model from mccormick and huguenard (1992), data from kay & wong (1987), published in destexhe et al (1994). Taken from shu et al. (2006, 2007), model no. 135787, with no changes. The two papers contain electrophysiology results, reflected in the animal model info below, along with modeling study based on previous models.
• Runtime: 8.594
• Temperature: Model has temperature dependence, with q10 set to 3 and original kinetics at 22 deg C. Simulations done at 37 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp