Channel 155057-car

General data

• ICG id: 3369
• ModelDB id: 155057
• Reference: Papoutsi A, Sidiropoulou K, Cutsuridis V, Poirazi P (2013): Induction and modulation of persistent activity in a layer V PFC microcircuit model.

Metadata classes

• Animal Model: mammal
• Brain Area: layer 5, prefrontal cortex, cortex
• Neuron Region: soma, dendrites, apical dendrites
• Neuron Type: pyramidal cell, interneuron
• Runtime Q: Q2
• Subtype: R-type

Metadata generic

• Age: various
• Authors: Y Poirazi, C Gold, M Markaki, K Siridopoulu
• Comments: Ca r-type channel with medium threshold for activation used in distal dendritic regions, together with calh.mod, to help the generation of ca++ spikes in these regions. Uses channel conductance (not permeability), written by y poirazi, 2000. Updated to cvode by c gold, 2003, updated by m markaki, 2003, changed by sidiropoulou, 2007. The paper cites durstewitz et al. (2000), model no. 82849, and durstewitz & gabriel (2007), model no. 82784, as the references for the channel kinetics and mod files for this model. Note that sidiropoulou & poirazi (2012), model no. 144089, also appears to be a reference for many of the files. This file is from siridopoulou & poirazi (2012), model no. 144089, with no apparent changes to kinetics. Modeling study based on previous models of cortical networks. Model was constrained by various experimental data, see 2013 paper discussion section for a complete list. Most data came from rat, but also some from cat, rabbit and monkey, so the animal model is considered mammalian.
• Runtime: 7.357
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp