Channel 45539-cat_a

General data

• ICG id: 2891
• ModelDB id: 45539
• Reference: Traub RD, Contreras D, Whittington MA (2005): Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo.

Metadata classes

• Animal Model: rat
• Brain Area: layer 5, layer 2/3, cortex, auditory cortex, thalamocortical circuit, parietal cortex, layer 6, layer 4, barrel cortex
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell, fast rhythmic bursting (FRB), thalamocortical relay cell (TC, TCR), thalamic reticular (RE) cell, regular spiking (RS) cell, intrinsically bursting (IB) cell, fast-spiking (FS) cell, low-threshold spiking (LTS) cell, interneuron, stellate cell, spiny cell, nontufted cell, tufted cell
• Runtime Q: Q1 (fast)
• Subtype: T-type

Metadata generic

• Age: adult
• Authors: M Lazarewicz.
• Comments: Modeling based on traub et al. (1994) and traub et al. (2003c), conductances from traub et al. 2003 and cunningham et al. 2004. This mod file: kinetics used data in destexhe et al. (1996). T-type current version a for rd traub, 2005. This current is found in the model deeplts cells, traub made this model, modifying huguenard and prince 1992 as appeared in destexhe et al (1996). Modification by t morse for traub et al. (2005), model no. 20756. Original implementation by m lazarewicz, 2003. Note: uses nonspecific current, doesn't cause ca2+ influx. Model features modifications to kinetic equations from ancestor channel. Modeling study, with many neurons in the cortex and thalamus. This channel is one of two cat models used, with this one primarily for gabaergic cells like lts interneurons. The animal model info here is from electrophysiology experiments also in this paper, both in vivo and in vitro.
• Runtime: 7.082
• Temperature: Channel model has no temperature dependence. Experiments done at 34-37 deg C, simulations likely done at physiological temperatures.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp