Channel 144490-somacar

General data

• ICG id: 1435
• ModelDB id: 144490
• Reference: Sterratt DC, Groen MR, Meredith RM, van Ooyen A (2012): Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy.

Metadata classes

• Animal Model: Wistar, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma
• Neuron Type: pyramidal cell
• Runtime Q: Q1 (fast)
• Subtype: R-type

Metadata generic

• Age: P28-42
• Authors: Y Poirazi
• Comments: Ca r-type channel with medium threshold for activation used in somatic regions, has lower threshold for activation/inactivation and slower activation time constant than the same mechanism in dendritic regions, written by y poirazi 2001. Taken from poirazi et al. (2003), model no. 20212, with some changes in implementation but no apparent modification to kinetics or parameters. [this file is from the main directory of model] modeling study, identical to ancestor model save the addition of schaffer collateral spines to dendrites. Experimental results from calcium imaging. Animal model reflects the calcium imaging data. The model was also implemented in two new ca1 pn morphologies but their origin is not clear.
• Runtime: 7.187
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp