Channel 138082-FVNaG3e

General data

• ICG id: 996
• ModelDB id: 138082
• Reference: Gurkiewicz M, Korngreen A, Waxman SG, Lampert A (2011): Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation.

Metadata classes

• Animal Model: human
• Runtime Q: Q4 (slow)
• Subtype: 1.7

Metadata generic

• Authors: M Gurkiewicz
• Comments: Six state hmm kinetic scheme for the f1449v voltage-gated sodium channel nav1.7 from gurkiewicz et al. (2011). No model db ancestors. Channel kinetics come from experiments on transfected cells in this paper, no brain area or neuron is mentioned.
• Runtime: 6.104
• Temperature: No temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp