Channel 125152-NapIn

General data

• ICG id: 624
• ModelDB id: 125152
• Reference: Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010): Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents.

Metadata classes

• Animal Model: mouse
• Brain Area: hippocampus, CA1
• Neuron Region: unspecified
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: persistent

Metadata generic

• Age: P40-P60
• Authors: M Horstmann
• Comments: Persistent sodium current with inactivation. Experimental results and modeling. The animal model here is from the experiemntal results, the model is the same as the ancestor.
• Runtime: 4.55
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp