Channel 125152-Nap

General data

• ICG id: 623
• ModelDB id: 125152
• Reference: Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010): Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents.

Metadata classes

• Animal Model: mouse
• Brain Area: hippocampus, CA1
• Neuron Region: unspecified
• Neuron Type: pyramidal cell
• Runtime Q: Q1 (fast)
• Subtype: persistent

Metadata generic

• Age: P40-P60
• Authors: M Horstmann
• Comments: Persistent sodium channel from royeck et al. (2008), model no. 115356, with some modifications based on results in this paper. Experimental results and modeling. The animal model here is from the experiemntal results, the model is the same as the ancestor.
• Runtime: 4.344
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp