Channel 123897-na16

General data

• ICG id: 535
• ModelDB id: 123897
• Reference: Hu W, Tian C, Li T, Yang M, Hou H, Shu Y (2009): Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation.

Metadata classes

• Animal Model: rat
• Brain Area: layer 5, prefrontal cortex, cortex
• Neuron Region: unspecified
• Neuron Type: pyramidal cell
• Runtime Q: Q1 (fast)
• Subtype: 1.6

Metadata generic

• Age: P16-20
• Authors: Z Mainen.
• Comments: Sodium channel, hh style kinetics were fit to data from huguenard et al. (1988) and hamill et al. (1991), written by z mainen 1994. From mainen & sejnowski (1996), model no. 2488. With modification. Animal model is from in vitro and in vivo experiments in this paper. Channel models taken from previous study, also on layer 5 pyramidal cell.
• Runtime: 4.146
• Temperature: Model appears to have standard temperature dependence. However, ancestor model is designed to be run only at 37 deg C, so this may not be the case.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp