Channel 223955-na8stI1473M

General data

• ICG id: 4732
• ModelDB id: 223955
• Reference: Ben-Shalom R, Keeshen CM, Berrios KN, An JY, Sanders SJ, Bender KJ (2017): Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures.

Metadata classes

• Brain Area: cortex
• Neuron Region: unspecified
• Neuron Type: pyramidal cell
• Subtype: not specified

Metadata generic

• Authors: Ben-Shalom R, Keeshen CM,Berrios KN, An JY, Sanders SJ, Bender KJ
• Comments: : Eight state kinetic sodium channel gating scheme : Modified from k3st.mod, chapter 9.9 (example 9.7) : of the NEURON book : 12 August 2008, Christoph Schmidt-Hieber : : accompanies the publication: : Schmidt-Hieber C, Bischofberger J. (2010) : Fast sodium channel gating supports localized and efficient : axonal action potential initiation. : J Neurosci 30:10233-42
• Temperature: tadj = q10^((celsius - temp)/10)

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp