Channel 170030-naxn

General data

• ICG id: 3936
• ModelDB id: 170030
• Reference: Miceli F, Soldovieri MV, Ambrosino P, De Maria M, Migliore M, Migliore R, Taglialatela M (2015): Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits.

Metadata classes

• Animal Model: chinese hamster ovary (CHO) cell
• Brain Area: hippocampus, CA1
• Neuron Region: axon
• Neuron Type: pyramidal cell
• Subtype: not specified

Metadata generic

• Authors: M Migliore
• Comments: Na current for axon. No slow inact.; M.Migliore Jul. 1997; : added sh to account for higher threshold M.Migliore, Apr.2002.
• Temperature: celsius, qt=q10^((celsius-24)/10). Ephys done at 20-22 deg C, but no mention of simulation temperature.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp