Channel 149174-nad

General data

• ICG id: 3277
• ModelDB id: 149174
• Reference: Thomas EA, Petrou S (2013): Network-specific mechanisms may explain the paradoxical effects of carbamazepine and phenytoin.

Metadata classes

• Animal Model: rat
• Brain Area: hippocampus, dentate gyrus (DG)
• Neuron Region: unspecified
• Neuron Type: granule cell, basket cell, hilar mossy cell, hilar perforant-path associated (HIPP) cell
• Runtime Q: Q4 (slow)
• Subtype: not specified

Metadata generic

• Age: P18-P22
• Authors: E Thomas
• Comments: Sodium current, kinetic model based on the santhakumar et al. (2005) sodium channel that also allows binding to inactivated states. Adapted from na current in ichan2.mod of santhakumar et al. (2005), model no. 51781. Modeling study. Animal model is from model and ancestor for channels (santakumar et al. 2005), originally from aradi and holmes (1999), among others.
• Runtime: 6.95
• Temperature: Model has temperature dependence, with original kinetics at 6.3 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp