Channel 149100-Nap_Et2

General data

• ICG id: 3245
• ModelDB id: 149100
• Reference: Hay E, Schurmann F, Markram H, Segev I (2013): Preserving axosomatic spiking features despite diverse dendritic morphology.

Metadata classes

• Animal Model: rat
• Brain Area: layer 5, cortex
• Neuron Region: axon
• Neuron Type: pyramidal cell, tufted cell
• Runtime Q: Q2
• Subtype: persistent

Metadata generic

• Age: P14
• Authors: E Hay
• Comments: Persistent sodium current. Mtau deduced from text (said to be 6 times faster than for nata) so i used the equations from nat and multiplied by 6. Modeled according to kinetics derived from magistretti & alonso (1999), corrected rates using q10 = 2.3, target temperature 34, original 21. Taken from hay et al. (2011), model no. 139653, with no changes (identical mod file). Modeling study, with experiments originally described in le be et al. (2007). Animal model is from there.
• Runtime: 4.582
• Temperature: Model has temperature dependence, with q10 set to 2.3, to correct original kinetics at 21 deg C to simulation temperature here of 34 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp