Channel 115356-naxmig

General data

• ICG id: 268
• ModelDB id: 115356
• Reference: Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008): Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons.

Metadata classes

• Animal Model: mouse
• Brain Area: hippocampus, CA1
• Neuron Region: axon, axon initial segment (AIS)
• Neuron Type: pyramidal cell
• Runtime Q: Q3
• Subtype: not specified

Metadata generic

• Age: 17-21 days
• Authors: M Migliore.
• Comments: Na current for axon, no slow inactivation, implemented by m migliore jul 1997, from migliore et al. (1999), model no. 2796, with one modification: added sh to account for higher threshold. Experimental study along with modeling, with morphology from varona et al. (2000) and kinetics from migliore et al. (1999). The animal model info here is from the experiments in this paper.
• Runtime: 4.847
• Temperature: Model has temperature dependence, with default temperature of 24 deg C, and q10 from Migliore et al. (1999).

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp