Channel 87284-naxn

General data

• ICG id: 2475
• ModelDB id: 87284
• Reference: Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM (2010): Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study.

Metadata classes

• Animal Model: rat
• Brain Area: hippocampus, CA1
• Neuron Region: unspecified
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: not specified

Metadata generic

• Age: 7-14 weeks old.
• Comments: Na current for axon, no slow inactivation. Implemented by m. Migliore jul 1997, added sh to account for higher threshold 2002. From migliore et al. (2005), model no. 55035, with no changes to kinetics. Animal model taken from chen (2005) which is used to constrain model. Channel kinetics from previous studies on hippocampal pyramidal neuron (migliore et al. 2005)
• Runtime: 4.958
• Temperature: Model has temperature dependence, q10=2.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp