Channel 8210-na3h5

General data

Metadata classes

  • Animal Model: mammal
  • Brain Area: layer 5, cortex
  • Neuron Region: soma, dendrites, basal dendrites
  • Neuron Type: pyramidal cell
  • Runtime Q: Q1 (fast)
  • Subtype: fast

Metadata generic

  • Age: generic
  • Authors: ZF Mainen
  • Comments: Fast na+ channels, kinetics based on data obtained from rat neocortical neurons in huguenard et al. (1988) and hamill et al. (1991). Equations based on hodgkin-huxley (1952), similar but not identical to those used by mccormick and huguenard (1992). Modeling study, with dendritic morphology based on rat l5 pyramidal neuron, from d. Smetters and s. Nelson (unpublished). Geometry of initial segment based on cat layer 5 pyramidal cell (fariã±as and defelipe 1991). Two experimental references listed for the channels themselves, from rat cerebral cortex and guinea pig hippocampal ca1 neurons. The model is considered generic for this reason.
  • Runtime: 9.265
  • Temperature: Model has temperature dependence, with q10 set to 2.3 and original kinetics at 23 deg C.

Current Response Traces

Action Potential