Channel 2488-na

General data

Metadata classes

  • Animal Model: generic
  • Brain Area: layer 5, layer 2/3, cortex, layer 4
  • Neuron Region: soma, dendrites, axon, axon initial segment (AIS), axon nodes (nodes of ranvier)
  • Neuron Type: pyramidal cell, aspiny cell, stellate cell
  • Runtime Q: Q1 (fast)
  • Subtype: not specified

Metadata generic

  • Age: generic
  • Authors: Z Mainen
  • Comments: Hodgkin-huxley style kinetics, fit to data from huguenard et al. (1988) and hamill et al. (1991). Low channel density in soma and dendrites, high density in axon hillock and initial segment. Dendritic chans important for generation of bursts and spike after-depolarizations. Designed only to be used at 37 deg c. Adapted from mainen et al. (1995), model no. 8210, with various modifications. Modeling study that takes kv and na kinetics from mainen et al. (1995), and introduces four neuron morphologies from cortex. No animal models are mentioned here and nothing related to where the morphologies came from, so it is considered generic. Na kinetics were originally from rat cortex (hamill et al. 1991).
  • Runtime: 4.409
  • Temperature: Model appears to have temperature dependence, with q10 set to 2.3 and original kinetics at 23 deg C. HOWEVER see note in mod files - models are meant to be used only at 37 deg C.

Current Response Traces

Action Potential