Channel 139653-NaTs2_t

General data

• ICG id: 1092
• ModelDB id: 139653
• Reference: Hay E, Hill S, Schurmann F, Markram H, Segev I (2011): Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties.

Metadata classes

• Animal Model: Wistar, rat
• Brain Area: layer 5, cortex
• Neuron Region: soma, dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: fast

Metadata generic

• Age: P36
• Authors: E Hay
• Comments: Fast inactivating na current. From colbert and pan (2002), took the nata and shifted both activation/inactivation by 6 mv. No modeldb ancestors. Modeling study, that is constrained by experimental data (animal model here) (see le be et al. 2007). Channel kinetics come from various sources.
• Runtime: 4.491
• Temperature: Model has temperature dependence. Original temperature is 21 deg C. Here, qt is set to 2.3, to adjust kinetics for simulations at 34 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp