Channel 101629-kaprox

General data

• ICG id: 9
• ModelDB id: 101629
• Reference: Hemond P, Epstein D, Boley A, Migliore M, Ascoli GA, Jaffe DB (2008): Distinct classes of pyramidal cells exhibit mutually exclusive firing patterns in hippocampal area CA3b.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: CA3, hippocampus
• Neuron Region: soma, dendrites, axon
• Neuron Type: pyramidal cell
• Runtime Q: Q4 (slow)
• Subtype: A

Metadata generic

• Age: 4-6 weeks old
• Authors: M Migliore
• Comments: K-a (fast inactivating) channel. Paper cites migliore et al. (1999) and migliore (2003) for kinetics. Migliore (2003), model no 19696, is used because it has all channels. The following modifications exist: addition of shift parameter, sh, set to 24 (line 12). Experimental results (animal model info here) as well as modeling.
• Runtime: 8.081
• Temperature: Model has temperature dependence. Experiments done at 34 deg C, no mention of simulation temperature.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp