Channel 125152-kleck

General data

• ICG id: 628
• ModelDB id: 125152
• Reference: Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010): Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents.

Metadata classes

• Animal Model: mouse
• Brain Area: hippocampus, CA1
• Neuron Region: unspecified
• Neuron Type: pyramidal cell
• Runtime Q: Q1 (fast)
• Subtype: leak

Metadata generic

• Age: P40-P60
• Authors: M Horstmann
• Comments: Potassium leakage current. No apparent ancestors. Experimental results and modeling. The animal model here is from the experiemntal results, the model is the same as the ancestor.
• Runtime: 6.578
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp