Channel 229585-Kv33

General data

• ICG id: 4535
• ModelDB id: 229585
• Reference: Masoli S, Solinas S, D'Angelo E (2015): Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.

Metadata classes

• Animal Model: guinea pig
• Brain Area: cerebellum
• Neuron Region: unspecified
• Neuron Type: Purkinje cell
• Subtype: HH, fast, high threshold

Metadata generic

• Age: 2–3 months old
• Authors: Masoli S, Solinas S, D'Angelo E
• Comments: TITLE Voltage-gated potassium channel from Kv3 subunits COMMENT Voltage-gated potassium channel with high threshold and fast activation/deactivation kinetics KINETIC SCHEME: Hodgkin-Huxley (n^4) n'= alpha * (1-n) - betha * n g(v) = gbar * n^4 * ( v-ek ) The rate constants of activation (alpha) and deactivation (beta) were approximated by: alpha(v) = ca * exp(-(v+cva)/cka) beta(v) = cb * exp(-(v+cvb)/ckb) Parameters can, cvan, ckan, cbn, cvbn, ckbn are given in the CONSTANT block. Values derive from least-square fits to experimental data of G/Gmax(v) and taun(v) in Martina et al. J Neurophys. 97 (563-671, 2007. Model includes a calculation of Kv gating current Reference: Akemann et al., Biophys. J. (2009) 96: 3959-3976 Laboratory for Neuronal Circuit Dynamics RIKEN Brain Science Institute, Wako City, Japan http://www.neurodynamics.brain.riken.jp Date of Implementation: April 2007 Contact: akemann@brain.riken.jp Suffix from Kv3 to Kv3_3 ENDCOMMENT
• Temperature: q10=2.7, qt=q10^((celsius-22 (degC))/10 (degC))

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp