Channel 229585-Kv11

General data

• ICG id: 4534
• ModelDB id: 229585
• Reference: Masoli S, Solinas S, D'Angelo E (2015): Action potential processing in a detailed Purkinje cell model reveals a critical role for axonal compartmentalization.

Metadata classes

• Animal Model: guinea pig
• Brain Area: cerebellum
• Neuron Region: unspecified
• Neuron Type: Purkinje cell
• Subtype: HH, 1.1

Metadata generic

• Age: 2–3 months old
• Authors: Masoli S, Solinas S, D'Angelo E
• Comments: TITLE Voltage-gated low threshold potassium current from Kv1 subunits COMMENT NEURON implementation of a potassium channel from Kv1.1 subunits Kinetical scheme: Hodgkin-Huxley m^4, no inactivation Experimental data taken from: Human Kv1.1 expressed in xenopus oocytes: Zerr et al., J Neurosci 18, 2842, 2848, 1998 Vhalf = -28.8 +- 2.3 mV; k = 8.1+- 0.9 mV The voltage dependency of the rate constants was approximated by: alpha = ca * exp(-(v+cva)/cka) beta = cb * exp(-(v+cvb)/ckb) Parameters ca, cva, cka, cb, cvb, ckb were determined from least square-fits to experimental data of G/Gmax(v) and tau(v). Values are defined in the CONSTANT block. Model includes calculation of Kv gating current Reference: Akemann et al., Biophys. J. (2009) 96: 3959-3976 Laboratory for Neuronal Circuit Dynamics RIKEN Brain Science Institute, Wako City, Japan http://www.neurodynamics.brain.riken.jp Date of Implementation: April 2007 Contact: akemann@brain.riken.jp Suffix from Kv1 to Kv1_1 ENDCOMMENT
• Temperature: q10=2.7, qt = q10^((celsius-22 (degC))/10 (degC))

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp