Channel 229585-Kv11

General data

Metadata classes

  • Animal Model: guinea pig
  • Brain Area: cerebellum
  • Neuron Region: unspecified
  • Neuron Type: Purkinje cell
  • Subtype: HH, 1.1

Metadata generic

  • Age: 2–3 months old
  • Authors: Masoli S, Solinas S, D'Angelo E
  • Comments: TITLE Voltage-gated low threshold potassium current from Kv1 subunits COMMENT NEURON implementation of a potassium channel from Kv1.1 subunits Kinetical scheme: Hodgkin-Huxley m^4, no inactivation Experimental data taken from: Human Kv1.1 expressed in xenopus oocytes: Zerr et al., J Neurosci 18, 2842, 2848, 1998 Vhalf = -28.8 +- 2.3 mV; k = 8.1+- 0.9 mV The voltage dependency of the rate constants was approximated by: alpha = ca * exp(-(v+cva)/cka) beta = cb * exp(-(v+cvb)/ckb) Parameters ca, cva, cka, cb, cvb, ckb were determined from least square-fits to experimental data of G/Gmax(v) and tau(v). Values are defined in the CONSTANT block. Model includes calculation of Kv gating current Reference: Akemann et al., Biophys. J. (2009) 96: 3959-3976 Laboratory for Neuronal Circuit Dynamics RIKEN Brain Science Institute, Wako City, Japan Date of Implementation: April 2007 Contact: Suffix from Kv1 to Kv1_1 ENDCOMMENT
  • Temperature: q10=2.7, qt = q10^((celsius-22 (degC))/10 (degC))

Current Response Traces

Action Potential