Channel 157157-IA

General data

• ICG id: 4206
• ModelDB id: 157157
• Reference: Saudargiene A, Cobb S, Graham BP (2015): A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus.

Metadata classes

• Brain Area: hippocampus
• Neuron Region: unspecified
• Neuron Type: pyramidal cell, axo-axonic cell (AAC), basket cell, bistratified cell
• Subtype: not specified

Metadata generic

• Authors: Saudargiene A, Cobb S, Graham BP
• Comments: COMMENT IA channel Reference: 1. Zhang, L. and McBain, J. Voltage-gated potassium currents in stratum oriens-alveus inhibitory neurons of the rat CA1 hippocampus, J. Physiol. 488.3:647-660, 1995. Activation V1/2 = -14 mV slope = 16.6 activation t = 5 ms Inactivation V1/2 = -71 mV slope = 7.3 inactivation t = 15 ms recovery from inactivation = 142 ms 2. Martina, M. et al. Functional and Molecular Differences between Voltage-gated K+ channels of fast-spiking interneurons and pyramidal neurons of rat hippocampus, J. Neurosci. 18(20):8111-8125, 1998. (only the gkAbar is from this paper) gkabar = 0.0175 mho/cm2 Activation V1/2 = -6.2 +/- 3.3 mV slope = 23.0 +/- 0.7 mV Inactivation V1/2 = -75.5 +/- 2.5 mV slope = 8.5 +/- 0.8 mV recovery from inactivation t = 165 +/- 49 ms 3. Warman, E.N. et al. Reconstruction of Hippocampal CA1 pyramidal cell electrophysiology by computer simulation, J. Neurophysiol. 71(6):2033-2045, 1994. gkabar = 0.01 mho/cm2 (number taken from the work by Numann et al. in guinea pig CA1 neurons) ENDCOMMENT
• Temperature: No temperature dependence

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp