Channel 185858-km

General data

• ICG id: 3913
• ModelDB id: 185858
• Reference: Neymotin SA, McDougal RA, Bulanova AS, Zeki M, Lakatos P, Terman D, Hines ML, Lytton WW (2016): Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex.

Metadata classes

• Animal Model: generic
• Brain Area: cortex
• Neuron Region: unspecified
• Neuron Type: pyramidal cell, basket cell, regular spiking (RS) cell, fast-spiking (FS) cell, low-threshold spiking (LTS) cell, interneuron
• Subtype: m

Metadata generic

• Authors: Z Mainen
• Comments: M-type potassium channel, based on I-M (muscarinic K channel). Slow, non-inactivating. Original channel modified to allow variable time step and to correct an intitialization error (M Hines and R Scorcioni 2002). Original author: Zach Mainen, Salk Institue, 1995.
• Temperature: Kinetics for channels were scaled by Q10 from an experimental temperature (where available) to a simulation temperature of 37 Celsius. Q10 ¼ 3 was used when no experimental value was available. A

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp