Channel 185858-kdmc

General data

• ICG id: 3910
• ModelDB id: 185858
• Reference: Neymotin SA, McDougal RA, Bulanova AS, Zeki M, Lakatos P, Terman D, Hines ML, Lytton WW (2016): Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex.

Metadata classes

• Animal Model: generic
• Brain Area: cortex
• Neuron Region: unspecified
• Neuron Type: pyramidal cell, basket cell, regular spiking (RS) cell, fast-spiking (FS) cell, low-threshold spiking (LTS) cell, interneuron
• Subtype: D

Metadata generic

• Authors: B Suter
• Comments: K-D channel with activation for motor cortex. Based on K-A current for mitral cells from Wang et al (1996), by Migliore Jan. 2002. First version created using Migliore's kamt.mod as a starting template, and then the default parameter values were set to those found from MRF optimization for BS0284 model (Ben Suter 2011)
• Temperature: Kinetics for channels were scaled by Q10 from an experimental temperature (where available) to a simulation temperature of 37 Celsius. Q10 ¼ 3 was used when no experimental value was available. A

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp