Channel 118986-kmquad

General data

• ICG id: 385
• ModelDB id: 118986
• Reference: Miceli F, Soldovieri MV, Lugli L, Bellini G, Ambrosino P, Migliore M, del Giudice EM, Ferrari F, Pascotto A, Taglialatela M (2009): Neutralization of a unique, negatively-charged residue in the voltage sensor of K V 7.2 subunits in a sporadic case of benign familial neonatal seizures.

Metadata classes

• Animal Model: human
• Brain Area: hippocampus, CA1
• Neuron Region: soma, axon
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: m

Metadata generic

• Age: various
• Authors: M Migliore
• Comments: Ca1 kv7.2-d212g channel from m. Taglialatela, implemented by m. Migliore oct 2008. From shah et al. (2008), model no. 112546, with various modifications. Fit to the data in this paper. Results from clinical experiments for kv7 channel, then combined into the ca1 model from the ancestor (rat). The experiments in the paper are used to modify the kinetics of the km current.
• Runtime: 7.665
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp