Channel 118986-kaprox

General data

• ICG id: 383
• ModelDB id: 118986
• Reference: Miceli F, Soldovieri MV, Lugli L, Bellini G, Ambrosino P, Migliore M, del Giudice EM, Ferrari F, Pascotto A, Taglialatela M (2009): Neutralization of a unique, negatively-charged residue in the voltage sensor of K V 7.2 subunits in a sporadic case of benign familial neonatal seizures.

Metadata classes

• Animal Model: human
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, proximal dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q3
• Subtype: A

Metadata generic

• Age: various
• Authors: M Migliore
• Comments: K-a channel from shah et al. (2008), model no. 112546, without modification (identical mod file). Results from clinical experiments for kv7 channel, then combined into the ca1 model from the ancestor (rat). The experiments in the paper are not used to modify the kinetics of the ka current.
• Runtime: 7.98
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp