Channel 170030-kaprox

General data

• ICG id: 3672
• ModelDB id: 170030
• Reference: Miceli F, Soldovieri MV, Ambrosino P, De Maria M, Migliore M, Migliore R, Taglialatela M (2015): Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits.

Metadata classes

• Animal Model: chinese hamster ovary (CHO) cell
• Brain Area: hippocampus, CA1
• Neuron Region: unspecified
• Neuron Type: pyramidal cell
• Subtype: A

Metadata generic

• Authors: M Migliore
• Comments: K-A channel from Klee Ficker and Heinemann modified to account for Dax A Current --- M.Migliore Jun 1997 modified to be used with cvode M.Migliore 2001.
• Temperature: celsius (degC). Ephys done at 20-22 deg C, but no mention of simulation temperature.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp