Channel 45539-kdr_fs

General data

• ICG id: 2903
• ModelDB id: 45539
• Reference: Traub RD, Contreras D, Whittington MA (2005): Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo.

Metadata classes

• Animal Model: rat
• Brain Area: layer 5, layer 2/3, cortex, auditory cortex, thalamocortical circuit, parietal cortex, layer 6, layer 4, barrel cortex
• Neuron Region: soma, dendrites, axon
• Neuron Type: pyramidal cell, fast rhythmic bursting (FRB), thalamocortical relay cell (TC, TCR), thalamic reticular (RE) cell, regular spiking (RS) cell, intrinsically bursting (IB) cell, fast-spiking (FS) cell, low-threshold spiking (LTS) cell, interneuron, stellate cell, spiny cell, nontufted cell, tufted cell
• Runtime Q: Q2
• Subtype: delayed rectifier (dr)

Metadata generic

• Age: adult
• Authors: M Lazarewicz.
• Comments: Modeling based on traub et al. (1994) and traub et al. (2003c), conductances from traub et al. 2003, model no. 20756, and cunningham et al. 2004. Kinetics based on martina et al. (1998). This file: potassium dr type current for fast-spiking (fs) interneurons for rd traub 2005. Modification in minf from ancestor version (line 59). Implemented by m lazarewicz. Modeling study, with many neurons in the cortex and thalamus. This channel model is primarily for gabaergic cells, such as fast spiking interneurons. The animal model info here is from electrophysiology experiments also in this paper, both in vivo and in vitro.
• Runtime: 7.41
• Temperature: Channel model has no temperature dependence. Experiments done at 34-37 deg C, simulations likely done at physiological temperatures.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp