Channel 45539-ka_ib

General data

• ICG id: 2896
• ModelDB id: 45539
• Reference: Traub RD, Contreras D, Whittington MA (2005): Combined experimental/simulation studies of cellular and network mechanisms of epileptogenesis in vitro and in vivo.

Metadata classes

• Animal Model: rat
• Brain Area: layer 5, layer 2/3, cortex, auditory cortex, thalamocortical circuit, parietal cortex, layer 6, layer 4, barrel cortex
• Neuron Region: soma, dendrites, axon
• Neuron Type: pyramidal cell, fast rhythmic bursting (FRB), thalamocortical relay cell (TC, TCR), thalamic reticular (RE) cell, regular spiking (RS) cell, intrinsically bursting (IB) cell, fast-spiking (FS) cell, low-threshold spiking (LTS) cell, interneuron, stellate cell, spiny cell, nontufted cell, tufted cell
• Runtime Q: Q2
• Subtype: A

Metadata generic

• Age: adult
• Authors: T Morse, M Lazarewicz.
• Comments: Modeling based on traub et al. (1994) and traub et al. (2003c), conductances from traub et al. 2003, model no. 20756, and cunningham et al. 2004. Kinetics based on data in huguenard and mccormick (1992) and mccormick and huguenard (1992), with only the faster components of inactivation was used, and the activation variable m was first order. This file: current specifically for tuftib (intrinsic bursting) cell, modified by t morse from ancestor channel with a 2.6 times htau (line 69), implementation by m lazarewicz, 2003. Modeling study, with many neurons in the cortex and thalamus. This channel model is primarily used for ib tufted pyramidal cells and potentially other cell types. The animal model info here is from electrophysiology experiments also in this paper, both in vivo and in vitro.
• Runtime: 7.506
• Temperature: Channel model has no temperature dependence. Experiments done at 34-37 deg C, simulations likely done at physiological temperatures.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp