Channel 146026-IKM

General data

• ICG id: 2831
• ModelDB id: 146026
• Reference: Bahl A, Stemmler MB, Herz AV, Roth A (2012): Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data.

Metadata classes

• Animal Model: rat
• Brain Area: somatosensory cortex, layer 5, cortex
• Neuron Region: soma
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: m

Metadata generic

• Age: 17-25 days old
• Authors: A Destexhe.
• Comments: Cortical m current, responsible for the adaptation of firing rate and the afterhyperpolarization (ahp) of cortical pyramidal cells. First-order model described by hh like equations. K+ current, activated by depolarization, non inactivating. Model taken from yamada, koch and adams (1989). See also mccormick et al (1993). Written by a destexhe, 1995. Ancestor model from winograd et al. (2008), model no. 113997, with several changes including renamed suffix and addition of vshift parameter. Modeling study that uses experimental data (somatic voltage responses) from bekkers and hausser (2007), which is reflected in the animal model here. Ancestor channel from study on prefrontal cortex (winograd et al., 2008).
• Runtime: 7.345
• Temperature: Experiments referenced in paper (Bekkers & Hausser 2007) done at 32-34 deg C, simulations assumed to be the same. q10 value assumed to be 2.3, and channel kinetics are at 36 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp