Channel 127305-kaprox

General data

• ICG id: 2733
• ModelDB id: 127305
• Reference: Hao J, Wang XD, Dan Y, Poo MM, Zhang XH (2009): An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, proximal dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q4 (slow)
• Subtype: A

Metadata generic

• Age: P16-21
• Authors: M Migliore
• Comments: K-a current from migliore et al. (1999), modified by brannon and y poirazi to account for hoffman et al 1997 distal region kinetics. Used only in sections < 100 microns from the dendrites and in soma. Note that this paper never says explicitly which reference it took ion channel kinetics from, but here we use poirazi et al. (2003), model no. 20212, because it is cited in the appendix as being a source of parameters. The animal model info is from the experimental results here, but the model parameters were taken from a previous modeling paper.
• Runtime: 8.185
• Temperature: Model has temperature dependence, with q10 set to 5 and original kinetics at 24 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp