Channel 98005-kcnq_ch

General data

• ICG id: 2647
• ModelDB id: 98005
• Reference: Maurice N, Mercer J, Chan CS, Hernandez-Lopez S, Held J, Tkatch T, Surmeier DJ (2004): D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons.

Metadata classes

• Animal Model: Sprague-Dawley, mouse, rat, C57BL/6
• Brain Area: basal ganglia, striatum (basal ganglia)
• Neuron Region: soma, dendrites
• Neuron Type: interneuron, cholinergic
• Runtime Q: Q4 (slow)
• Subtype: m

Metadata generic

• Age: 3-5 weeks
• Authors: J Held
• Comments: Kcnq/m current from striatal medium spiny neurons, used for ch. Interneuron. Markov model from raman and bean (2001), taddese and bean (2002), carr et al. (2003), fit to experimental data. No apparent model db ancestor. Animal model is from experiments in paper.
• Runtime: 8.437
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp