Channel 9769-kaprox

General data

• ICG id: 2548
• ModelDB id: 9769
• Reference: Poolos NP, Migliore M, Johnston D (2002): Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, proximal dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q4 (slow)
• Subtype: A

Metadata generic

• Age: 6-10 weeks old
• Authors: M Migliore
• Comments: K-a current for proximal dendrites from migliore et al. (1999), model no. 2796 (from klee, ficker and heinemann (1995), modified to account for dax a current). Implemented by m.migliore jun 1997. Identical to ancestor channel. This paper features experimental data as well as modeling. The animal model info below reflects the experimental data here, although this did not change the implementation of ka, which remained the same. Both the ancestor and this current model feature rat ca1 pyramidal neuron.
• Runtime: 8.037
• Temperature: Model has temperature dependence.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp