Channel 87585-ichanWT2005

In other classes Na

General data

• ICG id: 2499
• ModelDB id: 87585
• Reference: Barela AJ, Waddy SP, Lickfett JG, Hunter J, Anido A, Helmers SL, Goldin AL, Escayg A (2006): An epilepsy mutation in the sodium channel SCN1A that decreases channel excitability.

Metadata classes

• Animal Model: generic
• Neuron Region: single compartment
• Neuron Type: generic
• Runtime Q: Q2
• Subtype: HH

Metadata generic

• Authors: J Lickfett, A Goldin
• Comments: Nav1.1 and kdr channels. Nav1.1 wild-type channel model described in barela et al. (2006), derived from the model in spampanato et al (2004a,b). Written by j lickfett 2005. Potassium kinetics similar to models in aradi and holmes (1999), aradi and soletz (2002), yuen and durand (1991), sodium kinetics fit to experimental data. No apparent modeldb ancestors modeling study, based on some human data and other. It is considered generic here.
• Runtime: 5.255
• Temperature: Model has temperature dependence, with original kinetics at 6.3 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp