Channel 87585-ichanR859C1

In other classes Na

General data

• ICG id: 2498
• ModelDB id: 87585
• Reference: Barela AJ, Waddy SP, Lickfett JG, Hunter J, Anido A, Helmers SL, Goldin AL, Escayg A (2006): An epilepsy mutation in the sodium channel SCN1A that decreases channel excitability.

Metadata classes

• Runtime Q: Q2
• Subtype: HH

Metadata generic

• Authors: J Lickfett, A Goldin
• Comments: Nav1.1 and Kdr channels. The R859C mutation (w/ B1) described in Barela et al. (2006), derived from Spampanato et al (2004a,b). Potassium kinetics similar to models in Aradi and Holmes (1999), Aradi and Soletz (2002), Yuen and Durand (1991), sodium kinetics fit to experimental data. No apparent modelDB ancestors.
• Runtime: 4.7
• Temperature: Model has temperature dependence, with original kinetics at 6.3 deg C.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp