Channel 3454-lt

General data

• ICG id: 1817
• ModelDB id: 3454
• Reference: Wang LY, Gan L, Forsythe ID, Kaczmarek LK (1998): Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones.

Metadata classes

• Animal Model: mouse
• Brain Area: medial nucleus of trapezoid body (MNTB) (brainstem)
• Neuron Type: MNTB neuron
• Runtime Q: Q2
• Subtype: low threshold

Metadata generic

• Age: P8-14
• Authors: D Kornfeld
• Comments: Low threshold potassium channel, supposedly prevents the cell from firing multiple spikes during prolonged depolarization. Parameters obtained by a direct fit to traces recorded from mouse mntb neurons. No modeldb ancestors. Animal model is from experiments in paper. Channel kinetics adapted from previous models, fit do traces in this paper.
• Runtime: 7.684
• Temperature: No temperature dependence. Experiments were done at room temperature (20-22 deg C), used to fit kinetics.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp