Channel 2796-kaprox

General data

• ICG id: 1732
• ModelDB id: 2796
• Reference: Migliore M, Hoffman DA, Magee JC, Johnston D (1999): Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons.

Metadata classes

• Animal Model: Sprague-Dawley, rat
• Brain Area: hippocampus, CA1
• Neuron Region: soma, dendrites, proximal dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q3
• Subtype: A

Metadata generic

• Age: 5-8 weeks old
• Authors: M Migliore
• Comments: K-a channel from experiments/model in hoffman et al. (1997), referenced as klee ficker and heinemann (1995) in the mod file, modified to account for dax a current (hoffman et al.). Used in soma, basal dendrites, and apical dendrites less than 100 um from soma. 2796_kadist.mod has an activation curve shifted by -12mv with respect to 2796_kaprox.mod. A temperature of 35 deg c assumed for all simulations. No modeldb ancestors. This is a modeling study based on experimental work from the two previous virtual nodes (hoffman et al. 1997; klee, ficker and heinemann 1995). The animal model info listed here comes from these virtual nodes.
• Runtime: 7.976
• Temperature: Model has standard temperature dependence. The temperature was 35 deg C for all simulations.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp