Channel 20007-KdrM99SL

General data

• ICG id: 1595
• ModelDB id: 20007
• Reference: Lazarewicz MT, Migliore M, Ascoli GA (2002): A new bursting model of CA3 pyramidal cell physiology suggests multiple locations for spike initiation.

Metadata classes

• Animal Model: rat
• Brain Area: CA3, hippocampus
• Neuron Region: soma, dendrites, apical dendrites, basal dendrites
• Neuron Type: pyramidal cell
• Runtime Q: Q2
• Subtype: delayed rectifier (dr)

Metadata generic

• Age: 33-57 days old
• Authors: M Migliore
• Comments: K-dr channel from migliore et al. (1999), model no. 2796 (from klee, ficker and heinemann (1995) as well as hoffman et al. (1997), modified to account for dax a current). By m. Migliore jun 1997. Kinetics from milgiore et al. (1999), distribution from hoffman et al. (1997). No apparent changes to kinetics. Strictly a modeling study, in which the ancestor ca1 model is adapted to a ca3 morphology. The animal model info below is from the morphology used here, from ishizuka et al. (1990).
• Runtime: 7.523
• Temperature: Model has temperature dependence. Hill coefficient (Q10) used in kinetics corresponds to a temperature of 25 deg C for simulation.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp