Channel 19176-HH2

In other classes Na

General data

• ICG id: 1544
• ModelDB id: 19176
• Reference: Wang J, Chen S, Nolan MF, Siegelbaum SA (2002): Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling.

Metadata classes

• Animal Model: generic
• Brain Area: thalamus
• Neuron Type: thalamocortical relay cell (TC, TCR)
• Runtime Q: Q4 (slow)
• Subtype: HH

Metadata generic

• Authors: A Destexhe.
• Comments: Hippocampal hh channels: fast na+ and k+ currents responsible for action potentials, from traub & miles (1991), written by a destexhe aug 1992. Paper cites the following two references for model: mccormick & huguenard (1992) and destexhe et al. (1996), model no. 3343. Identical to ancestor model. Modeling uses previous study on the thalamocortical circuit. No animal model mentioned in paper so it is considered generic.
• Runtime: 5.019
• Temperature: Experiments done at 22 deg C, simulations at 36 deg C, q10=4 for model.

Current Response Traces

Activation

Inactivation

Deactivation

Action Potential

Ramp